Please enter parameters in left column below: 


Results: 
Disease Prevalence K (<1): 


Maximum AUC from a genomic profile that explains all
the genetic variance, AUC_{max} (eq 3): 

Either 


Maximum AUC from a genomic profile that explains half
of the genetic variance, AUC_{half}: 

Sibling recurrence or risk λ_{s} (>1): 


Maximum AUC from a genomic profile that explains a quarter of
the genetic variance, AUC_{quar}: 

Or 


Maximum AUC from 2 parent family history, AUC_{FH:2parent} (eq S1): 

Heritability of liability h ^{2}_{L} (01): 


Where AUC estimate is provided: 



Proportion of variance explained on the
liability scale, h^{2}_{L[x]} (eq 4): 

Optional 


Proportion of genetic variance explained on the
liability scale, ρ^{2}_{GhatG} (eq 5): 

Estimated AUC (0.51): 


Sibling risk explained by genomic profile, λ_{s[x]} (uses eq 6): 




Proportion of total sibling risk explained, (λ_{s[x]} 1)/(λ_{s}  1): 




Interim Calculations: 




Threshold T: 




Height of normal curve at T, z: 




Mean liability of diseased group = "selection intensity", i: 




Proportion of sibs affected, K_{S}: 




Threshold for sibs T_{1} (see eq 1): 




Threshold for sibs on profile, T_{1[x]} (see eq 6): 
